Melanotan-1 – 10mg

Verified Research Quality

Every batch of Melanotan-1 supplied by Rejuven8 undergoes rigorous batch-specific analytical verification to confirm identity, purity, and net peptide content.

Rejuven8 Research Standard

✓ ≥99% Analytical Purity
✓ Third-Party Analytical Testing
✓ HPLC Verification
✓ Mass Spectrometry Identity Confirmation
✓ Batch-Specific Certificate of Analysis

Certificate of Analysis

Batch testing includes:

• High-Performance Liquid Chromatography (HPLC)
• Mass Spectrometry Identity Verification
• Analytical Purity Confirmation

Melanotan-1 (MT-1) Research Overview

Melanotan-1, also designated MT-1, afamelanotide, or [Nle4, D-Phe7]-alpha-MSH, is a synthetic linear analog of alpha-melanocyte-stimulating hormone (alpha-MSH). In laboratory research, Melanotan-1 is studied as a selective melanocortin-1 receptor (MC1R) agonist and as a tool compound for investigating the melanogenesis pathway and melanocortin-receptor signaling.

Unlike the non-selective analog Melanotan-2, which engages multiple melanocortin receptors (MC1R through MC5R), the MT-1 research profile is weighted toward MC1R, the receptor most associated with melanin-synthesis pathways in preclinical models.

Preclinical investigations have explored Melanotan-1 in experimental models studying:

• MC1R receptor binding and selectivity
• melanogenesis and melanin-synthesis pathways
• melanocyte signaling and gene-expression models
• photoprotection and UV-response research models
• melanocortin-receptor pharmacology and structure-activity relationships

Mechanistic Research Insights

Experimental research examines Melanotan-1 as an MC1R-selective melanocortin agonist, with downstream signaling studied primarily through the cyclic AMP (cAMP) pathway.

Areas of investigation include:

• MC1R activation and cAMP signaling
• tyrosinase and melanin-synthesis enzyme pathways
• eumelanin production in melanocyte models
• receptor selectivity relative to MC3R, MC4R, and MC5R
• structure-activity relationships among alpha-MSH analogs

These mechanisms are commonly studied in melanocyte cell cultures and receptor-binding assays.

Compound Information

Compound Name: Melanotan-1 (MT-1)
Alternate Designations: Afamelanotide, [Nle4, D-Phe7]-alpha-MSH, NDP-MSH
Peptide Class: Synthetic alpha-MSH Analog (Melanocortin Agonist)
Sequence: Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
Molecular Formula: C78H111N21O19
Molecular Weight: ~1646.9 g/mol
CAS Number: 75921-69-6

Product Specifications

Purity: ≥99%
Testing Methods: HPLC & Mass Spectrometry
Appearance: Lyophilized white powder
CAS Number: 75921-69-6

Each batch undergoes analytical verification to confirm peptide identity, purity, and consistency.

Storage

For optimal stability, store lyophilized peptides in a cool, dry environment away from direct light. Long-term storage conditions may vary depending on laboratory requirements.

Research Use Notice

This compound is supplied strictly for laboratory research purposes only. Not intended for human consumption, therapeutic use, cosmetic use, or veterinary use.