GLP-1 SM

7x tested

GLP-1 SM is a synthetic, long-acting GLP-1 receptor agonist research peptide — an engineered analog of the native incretin, not the native hormone itself. It is supplied in lyophilized form, ≥99% analytical purity, for in-vitro and laboratory research into incretin signaling and metabolic regulation.

What is GLP-1 SM?

Within the Rejuven8 designation system the numeral says how many receptor targets a compound engages: GLP-1 SM acts at a single incretin receptor, the GLP-1 receptor; GLP-2 TZ at two (GLP-1 and GIP); GLP-3 RT at three (GLP-1, GIP and glucagon). The “SM” suffix identifies the specific single-receptor research compound in the series.

Searches and listings write it several ways — GLP1 SM, GLP-1SM, GLP 1 SM, or just “GLP-1 peptide”. On this page and on every Certificate of Analysis it is GLP-1 SM, and the COA’s identity line reads “GLP SM”.

GLP-1 SM is used as the single-receptor reference point when researchers compare incretin agonists: it isolates what GLP-1 receptor activation alone contributes before a second or third receptor is added. It is supplied strictly for laboratory research.

Rejuven8 Research Standard

Every batch of GLP-1 SM supplied by Rejuven8 undergoes batch-specific analytical verification to confirm identity, purity and net peptide content before it is listed.

Certificate of Analysis

✓ ≥99% Analytical Purity
✓ Third-Party Analytical Testing
✓ HPLC Verification
✓ Mass Spectrometry Identity Confirmation
✓ Net Peptide Content Verification
✓ Batch-Specific Certificate of Analysis

Each vial carries its batch number; the matching report is in our Certificates of Analysis library.

Research Overview

Researchers investigate GLP-1 SM to characterise GLP-1 receptor signaling on its own — the baseline against which dual- and triple-receptor analogs are measured. Areas commonly explored in experimental models include:

• GLP-1 receptor binding, activation and desensitization
• glucose-dependent insulinotropic signaling in vitro
• cAMP accumulation and downstream second-messenger assays
• receptor trafficking and β-arrestin recruitment
• comparative pharmacology against native GLP-1 and against multi-receptor analogs
• stability and half-life behaviour of albumin-binding peptide conjugates

These studies focus on how an engineered single-receptor incretin analog influences biological pathways involved in metabolic regulation.

Mechanistic Research Insights

GLP-1 SM is characterised in the literature as a protracted-action GLP-1 receptor agonist. Reported characteristics include:

• full agonism at the GLP-1 receptor with potency comparable to the native ligand
• DPP-4 resistance conferred by a non-natural residue substitution at position 8
• a fatty-diacid conjugate attached via a linker that binds serum albumin, extending half-life in preclinical models
• receptor selectivity: no meaningful activity reported at the GIP or glucagon receptors, which is what makes it the single-receptor comparator

Compound Information

Compound Name: GLP-1 SM
Peptide Class: GLP-1 Receptor Agonist (single-receptor incretin analog)
Structure: Synthetic linear peptide; non-natural residue substitutions; fatty-diacid conjugate via linker
Observed mass (LC-MS, lot COA): ~4.11 kDa — [M+3H]3+ 1371.7, [M+4H]4+ 1028.2

Product Specifications

Purity: ≥99%
Testing Methods: HPLC & Mass Spectrometry
Net Peptide Content: Verified
Appearance: Lyophilized white peptide powder
Vial sizes: several masses available — select above; each vial is a single lyophilized fill

Each batch undergoes analytical verification to confirm peptide identity, purity and net peptide content.

Storage

Store lyophilized vials in a cool, dry environment away from direct light: refrigerated (2 to 8 °C) for short-term storage, −20 °C for long-term. Keep sealed and desiccated until use. Reconstituted solutions have their own stability window and should be handled per your laboratory’s protocol.

Frequently Asked Questions

Is GLP-1 SM the same as native GLP-1?

No. Native GLP-1 (7-36) is a 30-residue hormone of about 3.3 kDa with a half-life of minutes. GLP-1 SM is an engineered analog: the lot COA’s mass confirmation reads about 4.1 kDa, the difference being the residue substitutions and the albumin-binding fatty-diacid conjugate that give it protracted action. If a listing elsewhere shows the native sequence, that is not this compound.

How is GLP-1 SM different from GLP-2 TZ and GLP-3 RT?

By receptor count. GLP-1 SM engages the GLP-1 receptor only; GLP-2 TZ engages GLP-1 and GIP; GLP-3 RT engages GLP-1, GIP and the glucagon receptor. Researchers comparing single, dual and triple agonism in the same assay typically run all three.

What does the Certificate of Analysis show?

HPLC purity, mass-spectrometry identity confirmation and net peptide content for the specific batch, from an independent laboratory. Match the batch number on your vial to the report in the COA library.

How should lyophilized GLP-1 SM be stored?

Sealed, dry, away from light; refrigerated short-term, frozen at −20 °C long-term. Avoid repeated freeze–thaw of reconstituted material; aliquot if your protocol requires multiple draws.

What is used to reconstitute it in the laboratory?

Lyophilized peptides are brought into solution with a laboratory-grade solvent chosen for the application. For multi-session research workflows that is usually bacteriostatic water; preservative-free sterile water is used where a protocol requires it. We do not provide usage or dosing guidance.

Which vial sizes are available, and how fast does it ship?

Several lyophilized masses — select the size above; every size is tested the same way and carries its own batch COA. Orders placed before 3PM EST ship the same day with tracking.

Is GLP-1 SM for human use?

No. GLP-1 SM is supplied strictly for laboratory research. It is not for human consumption, therapeutic or veterinary use, and not for any form of self-administration.

Research Use Notice

This compound is supplied strictly for laboratory research purposes only. Not intended for human consumption, therapeutic use, or veterinary use.