GLP-2 TZ

GLP-2 TZ is a synthetic long-acting research peptide that activates two incretin receptors — GIP and GLP-1 — from a single molecule, supplied in lyophilized form for in-vitro and laboratory research into metabolic signaling.

Rejuven8 Research Standard

Every batch of GLP-2 TZ supplied by Rejuven8 undergoes rigorous batch-specific analytical verification to ensure quality, purity, identity, and net peptide content.

Certificate of Analysis

✓ ≥99% Analytical Purity
✓ Third-Party Analytical Testing
✓ HPLC Verification
✓ Mass Spectrometry Identity Confirmation
✓ Net Peptide Content Verification
✓ Batch-Specific Certificate of Analysis

Research Overview

Within the Rejuven8 designation system, the numeral indicates how many receptor targets a compound engages — GLP-1 SM acts at a single incretin receptor, GLP-2 TZ at two, and GLP-3 RT at three.

Researchers investigate GLP-2 TZ to understand what a second incretin receptor contributes to metabolic signaling beyond GLP-1 receptor activation alone.

Areas commonly explored include:

• dual GIP and GLP-1 receptor signaling pathways
• glucose-dependent insulinotropic mechanisms
• GIP receptor biology in adipose tissue
• energy balance and nutrient partitioning models
• receptor trafficking and signaling bias

These studies focus on understanding how engineered incretin analogs influence biological pathways involved in metabolic regulation.

Mechanistic Research Insights

GLP-2 TZ is studied as an imbalanced and biased dual agonist. Reported characteristics include:

• activity at the GIP receptor comparable to the native ligand
• weaker relative activity at the GLP-1 receptor than native GLP-1
• signaling biased toward cAMP over β-arrestin recruitment
• reduced receptor internalization and slower desensitization
• DPP-4 resistance conferred by non-natural residue substitution
• extended half-life via albumin-binding fatty diacid conjugation

Compound Information

Compound Name: GLP-2 TZ
Peptide Class: Dual Incretin Receptor Agonist (GIP / GLP-1)
Structure: Synthetic 39-amino-acid linear peptide, C-terminally amidated
Modifications: Non-natural residue substitutions; C20 fatty diacid conjugate

Product Specifications

Purity: ≥99%
Testing Methods: HPLC & Mass Spectrometry
Net Peptide Content: Verified
Appearance: Lyophilized white peptide powder

Each batch undergoes analytical verification to confirm peptide identity, purity, and net peptide content.

Storage

For optimal stability, store lyophilized peptides in a cool, dry environment away from direct light.

Long-term storage conditions may vary depending on laboratory requirements.

Research Use Notice

This compound is supplied strictly for laboratory research purposes only.

Not intended for human consumption, therapeutic use, or veterinary use.