5-Amino-1MQ – 50mg

Verified Research Quality

Every batch of 5-Amino-1MQ supplied by Rejuven8 undergoes rigorous batch-specific analytical verification to confirm identity, purity, and net compound content.

Rejuven8 Research Standard

✓ ≥99% Analytical Purity

✓ Third-Party Analytical Testing

✓ HPLC Verification

✓ Mass Spectrometry Identity Confirmation

✓ Batch-Specific Certificate of Analysis

Certificate of Analysis

Batch testing includes:

• High-Performance Liquid Chromatography (HPLC)
• Mass Spectrometry Identity Verification
• Analytical Purity Confirmation

5-Amino-1MQ Research Overview

5-Amino-1MQ, chemically designated 5-amino-1-methylquinolinium, is a small-molecule, membrane-permeable inhibitor of nicotinamide N-methyltransferase (NNMT). In laboratory research, 5-Amino-1MQ is studied as a tool compound for investigating the NAD+ salvage pathway, cellular methylation balance, and adipocyte energy metabolism.

NNMT consumes nicotinamide — the NAD+ precursor — and the methyl donor SAM, positioning the enzyme at the intersection of cellular energetics and methylation status. Selective NNMT inhibition has made 5-Amino-1MQ a frequent reference compound in preclinical metabolic research.

Preclinical investigations have explored 5-Amino-1MQ in experimental models studying:

• NNMT enzyme inhibition and selectivity
• NAD+ salvage-pathway flux and cellular NAD+ levels
• adipocyte lipogenesis and whole-body metabolism models
• diet-induced obesity research models
• muscle-stem-cell function in aged-tissue models

Mechanistic Research Insights

Experimental research examines 5-Amino-1MQ through its inhibition of NNMT, with downstream effects studied across NAD+-dependent signaling pathways.

Areas of investigation include:

• reduction of 1-methylnicotinamide (1-MNA) formation
• increases in intracellular NAD+ and SAM in cellular models
• sirtuin-pathway activity linked to NAD+ availability
• adipocyte gene-expression and lipogenesis programs
• cellular energy expenditure in metabolic research models

These mechanisms are commonly studied in adipocyte cultures and rodent metabolic models.

Compound Information

Compound Name: 5-Amino-1MQ

Alternate Designations: 5-amino-1-methylquinolinium, 5A-1MQ

Compound Class: Small-Molecule NNMT Inhibitor (Quinolinium)

Molecular Formula: C10H11N2+ (cation; supplied as salt)

Molecular Weight: ~159.2 g/mol (cation)

CAS Number: 42464-96-0

Product Specifications

Purity: ≥99%

Testing Methods: HPLC & Mass Spectrometry

Appearance: Powder

CAS Number: 42464-96-0

Each batch undergoes analytical verification to confirm compound identity, purity, and consistency.

Storage

For optimal stability, store in a cool, dry environment away from direct light. Long-term storage conditions may vary depending on laboratory requirements.

Research Use Notice

This compound is supplied strictly for laboratory research purposes only. Not intended for human consumption, therapeutic use, or veterinary use.